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<script>window._bd_share_config={"common":{"bdSnsKey":{},"bdText":"","bdMini":"2","bdMiniList":false,"bdPic":"","bdStyle":"0","bdSize":"16"},"share":{"tag":"share_1","bdSize":32,"bdCustomStyle":"http://ats.taiwan.cn/homepage2021/css/bgBdShare2021.css"}};with(document)0[(getElementsByTagName('head')[0]||body).appendChild(createElement('script')).src='http://103.249.53.35/gate/big5/bdimg.share.baidu.com/static/api/js/share.js?v=89860593.js?cdnversion='+~(-new Date()/36e5)];</script>  </div> </div> <div id="bdShareBtn"></div> </div>  </div> <div class="contentArea"> <div class=TRS_Editor><p style="text-align: center"><img style="border-left-width: 0px; border-right-width: 0px; border-bottom-width: 0px; border-top-width: 0px" alt="" oldsrc="W020190403570552067826.jpg" src="./W020190403570552067826.jpg" />　　</p> <p>　　<font face="楷體, 楷體_GB2312">臺灣“中央研究院”發現“果凍細胞”助病毒檢測、免疫治療。（圖片來源：臺灣“東森新聞雲”）</font></p> <p>　　台灣網4月3日訊據臺灣“東森新聞雲”報道，臺灣“中央研究院”生物醫學科學研究所胡哲銘助研員與研究團隊發現，在細胞中注入狀似果凍的水凝膠（PEG）後變成“果凍細胞”，可以在細胞死亡時保存細胞膜上蛋白質、醣類等生物活性，<b>有助於幹細胞研究、免疫治療以及病毒檢測技術研發。</b></p> <p>　　據報道，研究團隊指出，細胞膜的界面複雜且脆弱，當細胞死亡後，細胞骨架網路的分解會破壞細胞質與細胞膜中的支撐，進而導致膜破裂和崩解，過往許多研究若要保留細胞物質活性得經過繁瑣的步驟，而且也不能完整保存。此研究突破了細胞骨架網路會被分解與破壞的先天限制。</p> <p>　　胡哲銘研究團隊開發出一種新技術，透過水凝膠化細胞來保持細胞膜的流動性與細胞膜界面活性，借此保存細胞膜的生物特性長達30天以上，活性不減且具高度穩定性。胡哲銘表示，因水凝膠細胞質地類似果凍，也可稱為“果凍細胞”，不僅能保持細胞膜脂類的排列順序和細胞膜蛋白質移動性，也能維持細胞表面受體與病毒抗原之交互作用。實驗以抗原呈現細胞（antigen-presenting cells,APC）為研究標的，研究團隊將水凝膠注入抗原呈現細胞，再與T淋巴細胞結合。實驗結果顯示，成為果凍細胞的抗原呈現細胞，能有效促進T淋巴細胞的增生，有助免疫治療和病毒檢測的研發。</p> <p>　　研究團隊指出，果凍細胞的生產過程相對簡易，團隊先將活細胞冷凍並解凍，使細胞表面暫時產生細小穿孔，之後將活細胞浸泡于水凝膠製劑中，讓片段水膠可以滲入細胞，接著照射UV燈，進行光活化之化學反應，使其片段合成水凝膠聚合物，取代自然的細胞骨架網路，維持原本細胞外型。<b>細胞內注入水凝膠是突破性的新技術，通用於生物膜研究和生物醫學上構建人工細胞的細胞固定方法，將來可望應用於各種細胞膜所產生之交互作用引發的生物功能調控。</b>（台灣網王怡然）</p></div> <div class="editor f14">[責任編輯：王怡然]</div> </div>  <div class="page-number"> <script type="text/javascript"> createPageHTML(1, 0, "t20190403_12153858", "htm"); </script> </div>  </div>   <div 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